Effect of Maternal Adrenalectomy and Corticosterone Therapy on the Early Development of B-Cells in the Fetal Pancreatic Islet in the Rat.

• DOI: 10.1292/jvms.58.10_995
• Publication Date: 2011-08-16T06:10:01Z
• Authors: Suguru KOMATSU; Masako YAMAMOTO; Tatsuya TAKIZAWA; Mitsuyuki SHIRAI; Kazuyoshi ARISHIMA; Yasunobu EGUCHI
• Keywords: Corticosterone

Pregnant Wistar rats were divided into 3 groups, non-operated control, adrenalectomized, and adrenalectomized corticosterone-treated. Maternal adrenalectomy was performed on day 6 of gestation. Corticosterone therapy made from the at operation to observation. The growth pattern insulin-producing B-cells observed immunohistochemically histometrically days 12 16. results obtained as follows: From 15, maternal resulted in a significant retardation insulin-positive terms collective volume cells. corticosterone prevented this retardation. On 16, however, overcame suppressive effect adrenalectomy. These suggest that lack adrenocortical hormones causes B-cell early development, that, when once developed well, can grow independently hormones.