Femoral Nonunion Fracture Treated with Recombinant Human Bone Morphogenetic Protein-2 in a Dog.

• DOI: 10.1292/jvms.60.535
• Publication Date: 2002-10-09T03:07:09Z
• Authors: Teruo ITOH; Manabu MOCHIZUKI; Kaoru FUDA; Ryohei NISHIMURA; Satoru MATSUNAGA; Tsuyoshi KADOSAWA; Nobuo SASAKI
• Keywords: Femoral fracture; Debridement (dental); Human bone

This is the first report on successful treatment of spontaneous nonunion fracture a dog by use recombinant human bone morphogenetic protein-2 (rhBMP-2). A 4-year-old Pomeranian with 2-year history femoral was treated implantation rhBMP-2. The had received surgical correction twice prior to admission but radiography affected limb revealed typical figure fracture. Glossly, fractured ends were sclerotic and area between filled fibrous tissue. After debridement shaft fixed an 8-hole plate. rhBMP-2 at total dose 256 μg implanted synthetic carrier into 8-mm defect formed debridement. Callus formation responding radiographically observed 2 weeks after reached radiographic union 8 implantation. plate removed 9 months Any complications not for 5 removal