Propagation of Swine Hemagglutinating Encephalomyelitis Virus and Pseudorabies Virus in Dorsal Root Ganglia Cells

• DOI: 10.1292/jvms.71.595
• Publication Date: 2009-06-04T06:03:57Z
• Authors: Yoko HARA; Rie HASEBE; Yuji SUNDEN; Kenji OCHIAI; Eiichi HONDA; Yoshihiro SAKODA; Takashi UMEMURA
• Keywords: Pseudorabies; Encephalomyelitis; Neurotropic virus; Infectivity; Axoplasmic transport; Dorsal root ganglion

Swine hemagglutinating encephalomyelitis virus (HEV) causes or vomiting and wasting disease in suckling piglets. Neurotoropism of the has been demonstrated previous vivo studies. In present study, we investigated infectivity propagation HEV comparison with those pseudorabies (PRV), another neurotropic virus, using dorsal root ganglia cells newborn mice containing nerve non-neuronal cells. infected but did not infect cells, whereas PRV both cell types. By cytoskeletal inhibitors, it was suggested that within among depended on microtubules intermediate filaments indicating viruses may be transported between body axonal terminals neurons by fast flow.