Clinical practice guidelines for congenital hyperinsulinism

• DOI: 10.1297/cpe.26.127
• Publication Date: 2017-07-26T22:14:08Z
• Authors: Tohru Yorifuji; Reiko Horikawa; Tomonobu Hasegawa; Masanori Adachi; Shun Soneda; Masanori Minagawa; Shinobu Ida; Takeo Yonekura; Yoshiaki Kinoshita; Yutaka Kanamori; Hiroaki Kitagawa; Masato Shinkai; Hideyuki Sasaki; Masaki Nio
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article; 3. Good health

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. These guidelines were generated as a collaborative effort between The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons, and followed the official procedures of guideline generation to identify important clinical questions, perform a systematic literature review (April 2016), assess the evidence level of each paper, formulate the guidelines, and obtain public comments.