Perioperative low-molecular-weight heparin. Is it effective and safe

• DOI: 10.1302/0301-620x.77b5.7559695
• Publication Date: 2018-02-21T11:55:17Z
• Authors: D Warwick; GC Bannister; D Glew; A Mitchelmore; M Thornton; TJ Peters; S Brookes
• Keywords: Venography

In previous randomised clinical trials of thromboprophylaxis after total hip replacement, low-molecular-weight heparin has been given for an arbitrary 7 to 14 days. The risk factors are mainly perioperative and it is possible that a shorter course may be adequate. We assessed the safety effectiveness three-day course. 156 primary THR patients randomisation either control group or receive enoxaparin at 12 hours preoperatively 36 postoperatively. Thrombosis was diagnosed by routine venography. Haemorrhagic side-effects were measurement blood loss, soft-tissue descriptive scores wound discharge bruising leg. prevalence calf thrombosis 15.4% in 32.1% (p = 0.01); proximal 17.9% respectively (not significant). There no difference haemorrhagic discharge, but there more group.