[The effect of preoperative induction chemotherapy on long-term survival of patients with advanced squamous cell carcinoma of the oral cavity tongue].

• DOI: 10.13201/j.issn.1001-1781.2016.21.006
• Publication Date: 2016-11-05
• Authors: X R Zhang; Fengxia Yu; Honghong Yan; Guifang Tan; Yu Zhou; X K Liu
• Keywords: Induction chemotherapy; Univariate analysis; Primary tumor; Neck dissection; Complete response; T-stage

Objective:To discuss the long term efficency of preoperative induction chemotherapy(IC)±radiotherapy on patients with resectable stage Ⅲ or Ⅳ squamous cell carcinoma oral cavity tongue(SCCOT).Method:During June 1996 to December 2005, 73 locally advanced SCCOT treated preoperatively IC(3 cycle cisplatin and 5 fluorouracil) followed by surgery(resection primary tumor neck)±radiotherapy in Cancer Center Sun Yat-sen University were enrolled our study. Five-year overall survival rates(OS), local control rate reasons treatment failure analyzed retrospectively.Result:The follow-up time was 1.9 188.0 months, median 70.9 months.Among that, 24 cases(32.9%) still alive, which 23 is more than 10 years until deadline follow-up. After IC, 17 patients(23.3%) had clinical complete response; 44 patients(60.3%) a partial 12 patients(16.4%) no response progression, an 83.6%(65/73). On final surgical pathology, 14 patients(19.2%) pathological 59 patients(80.8%) histological incomplete response(residual tumor). Univariate analysis showed that size(P< 0.05), cervical lymphatic metastasis(P< 0.05),clinical stage(P< different remissions(P< not remission(P< 0.05) risk factors affecting prognosis(P< 0.05).Multivariate indicated metastasis remissions (P< independent for prognosis. OS effective IC 62.5%, apparently higher invalid effect 41.7% 0.05). pCR 92.9%, while have 47.9%(P< A significant difference between two groups also found. During whole time, 22 developed recurrence. 59.8%, 69.9%.Conclusion:IC plus surgery without postoperative radiotherapy modality tolerated encouraging activity outcome SCCOT. Response this regimen limited, but responders associated excellent