Probable Diltiazem-Induced Acute Interstitial Nephritis

• DOI: 10.1345/aph.17254
• Publication Date: 2004-03-11T22:08:19Z
• Authors: José A Abadín; José A Durán; José A Pérez de León
• Keywords: Maculopapular rash; Interstitial nephritis

OBJECTIVE: To describe a case of acute interstitial nephritis (AIN) probably related to administration diltiazem. CASE SUMMARY: A 53-year-old white man presented the hospital experiencing abdominal pain radiating both renal fossae, as well dysuria. Diltiazem and atenolol had been prescribed treat an episode precordial associated with effort. An erythematous maculopapular rash developed approximately 2 hours after single dose diltiazem, failure, elevated liver function test results, 6 days later. DISCUSSION: best our knowledge, this is third reported failure believed be induced by In all cases, there was obvious temporal relationship between diltiazem onset failure. Previous reports failed discuss probable pathogenic mechanism. AIN most likely etiology in patient. Favorable resolution no relapse, presence skin rash, sequelae suggest common immunoallergic CONCLUSIONS: Healthcare professionals should consider diltiazem-induced differential diagnosis patient taking who develops