Pretargeted radioimmunotherapy, a potential cancer treatment

• DOI: 10.1358/dof.2003.028.02.856929
• Publication Date: 2005-05-13T15:44:40Z
• Authors: Lam, L.; Liu, X.; Cao, Y.
• Keywords: Clearance

Radioimmunotherapy is often limited by radiation toxicity due to the long-circulating radiolabeledand body. Pretargeted radoimmunotherapy used mine imize this separating long-citrculating antibody and rapidly cleared radionuclide. Although results from animal studies clinical trials are promising, they have also raised many questions. Preclinical experiences will foster an in-depth understanding of pretargeted radioimmunotherapy as alternative, choice for cancer treatment. Breakthroughs in recombinant DNA technology , protein engineering, discovery alpha particle radionuclides their applications concerns designing human-clinical together.will expedite use setting