Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations With Anisotropic Elastic Moduli in Human Trabecular Bone

• DOI: 10.1359/jbmr.071009
• Publication Date: 2007-10-01T13:55:54Z
• Authors: X Sherry Liu; Paul Sajda; Punam K Saha; Felix W Wehrli; Grant Bevill; Tony M Keaveny; X Edward Guo
• Keywords: Trabecula (gastropod); Rod; Orthotropic material; X-ray microtomography

Abstract Trabecular plates and rods are important microarchitectural features in determining mechanical properties of trabecular bone. A complete volumetric decomposition individual was used to assess the orientation morphology 71 human bone samples. The ITS-based morphological analyses better characterize microarchitecture help predict anisotropic Introduction: Standard architecture lack explicit segmentations rods. In this study, a technique developed segment microstructure into Contributions type-associated parameters elastic moduli were studied. Materials Methods: Seventy-one samples from femoral neck (FN), tibia, vertebral body (VB) imaged using μCT or serial milling. Complete applied each trabecula determined, axial volume fractions (aBV/TV), axially aligned fraction along orthotropic axis, correlated with moduli. microstructural derived compared standard parameters. Their contributions moduli, calculated by finite element analysis (FEA), evaluated compared. Results: distribution suggested that longitudinal transverse dominate at all three anatomic sites. aBV/TV general, showed correlation modulus (r2 = 0.95∼0.99) BV/TV 0.93∼0.94). plate-associated generally higher correlations corresponding than rod-associated Multiple linear regression models six trabeculae segmentation (ITS)-based (adjusted r2 0.95∼0.98) performed equally well as those 0.94∼0.97) but revealed specific Conclusions: provide characterization loading is mainly sustained volume. Results suggest overall