Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice

• DOI: 10.1359/jbmr.2001.16.1.182
• Publication Date: 2006-04-27T03:05:53Z
• Authors: Farhad Parhami; Yin Tintut; Wesley G. Beamer; Nima Gharavi; William Goodman; Linda L. Demer
• Keywords: Male; Mice, Inbred C3H; 0303 health sciences; Lumbar Vertebrae; Arteriosclerosis; Osteocalcin; Bone Marrow Cells; Mice, Inbred C57BL; Radiography; Mice; 03 medical and health sciences; Calcification, Physiologic; Gene Expression Regulation; Bone Density; Osteogenesis; Animals; Diet, Atherogenic; Osteoporosis; Femur; RNA, Messenger

Abstract The epidemiological correlation between osteoporosis and cardiovascular disease is independent of age, but the basis for this unknown. We previously found that atherogenic oxidized lipids inhibit osteoblastic differentiation in vitro ex vivo, suggesting an diet may contribute to both diseases. In study, effects high-fat versus control chow on bone were tested two strains mice with genetically different susceptibility atherosclerosis lipid oxidation. After 4 months 7 diets, mineral content density measured excised femurs lumbar vertebrae using peripheral quantitative computed tomographic (pQCT) scanning. addition, expression osteocalcin marrow isolated from after diets was examined. months, femoral C57BL/6 atherosclerosis-susceptible 43% lower (0.73 ± 0.09 mg vs. 1.28 0.42 mg; p = 0.008), 15% compared diet. Smaller deficits observed months. Vertebral also fat-fed mice. These changes atherosclerosis-resistant, C3H/HeJ smaller mostly not significant. Osteocalcin reduced high findings suggest inhibits formation by blocking osteoblast progenitor cells.