Risk Factors for Fractures of the Proximal Humerus: Results From the EPIDOS Prospective Study

• DOI: 10.1359/jbmr.2002.17.5.817
• Publication Date: 2006-04-26T21:12:20Z
• Authors: Sun H. Lee; Patricia Dargent-...; Gérard Bréart
• Keywords: Hip Fracture

Abstract Fracture of the proximal humerus is one most frequent fractures attributable to osteoporosis; yet, it has seldom been studied. Two types factors (related bone fragility and falls) were evaluated identify risk for as well examine possible interactions between them. Subjects 6901 white women aged ≥75 years all participated in EPIDOS study osteoporotic (France, 1992-1998). The baseline examination included measurements femoral neck mineral density (BMD) calcaneal ultrasound parameters (speed sound [SOS] broadband attenuation [BUA]), a functional clinical examination, completing questionnaire on health status lifestyle. During mean 3.6 (0.8) follow-up, 165 had humeral fracture. Using multivariate Cox regression models, we identified three predictors related fragility—low BMD (relative [RR] = 1.4; 95% CI, 1.1-1.7), low SOS (RR 1.3; 1.0-1.6), maternal history hip fracture 1.8; 1.0-3.0)—and four fall-related predictors—a previous fall 3.0; 1.5-6.1), level physical activity 2.2; 1.1-4.4), impaired balance 1.1-2.9), pain lower limb extremity 1.0-2.1). effect these varied according level; they significantly associated with osteoporosis (BMD T score < −2.5) but not nonosteoporotic women. incidence (5.1 per 1000 woman-years) was only slightly higher than (4.6 similar without high (5.3 woman-years). On other hand, who both more two times (12.1 factors. These results suggest that have should receive highest priority prevention.