Monte Carlo-based inverse model for calculating tissue optical properties Part I: Theory and validation on synthetic phantoms

• DOI: 10.1364/ao.45.001062
• Publication Date: 2006-02-21T22:34:19Z
• Authors: Gregory M. Palmer; Nirmala Ramanujam
• Keywords: Diffuse reflection; Integrating sphere

A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction absorption scattering properties turbid media, such as human tissues. This method is valid a wide range optical easily adaptable to existing probe geometries, provided single phantom calibration measurement made. condensed Carlo was used speed up forward simulations. validated by use two sets liquid-tissue phantoms containing Nigrosin or hemoglobin absorbers polystyrene spheres scatterers. The had (0-20 cm−1) reduced coefficients (7-33 cm−1). Mie theory spectrophotometer were determine phantoms. spectra measured over wavelength 350-850 nm. It found that could be extracted from experimentally with an average error 3% less 12% Nigrosin.