In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

• DOI: 10.1364/boe.430935
• Publication Date: 2021-07-06T05:30:06Z
• Authors: Christopher G. Lui; Wihan Kim; James B. Dewey; Frank D. Macías-E...; Kumara Ratnayake; John S. Oghalai; Brian E. Applegate
• Keywords: Otology; Functional Imaging

We describe an optical coherence tomography and vibrometry system designed for portable hand-held usage in the otology clinic on awake patients. The provides clinically relevant point-of-care morphological imaging with 14-44 µm resolution functional vibratory measures sub-nanometer sensitivity. evaluated various new approaches extracting information including a multi-tone stimulus, continuous chirp alternating air bone stimulus. also explored response over area of tympanic membrane (TM) generated TM thickness maps. Our results suggest that can provide real-time vivo ear could prove useful investigating otologic pathology setting.