Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

• DOI: 10.1364/boe.505618
• Publication Date: 2023-11-24T15:00:05Z
• Authors: Oxana Semyachkina...; Ivan Fedosov; Alexey Zaikin; Vasily Ageev; Egor Ilyukov; Dmitry Myagkov; Dmitry Tuktarov; Inna Blokhina; Alexander Shirokov; Andrey Terskov; Daria Zlatogorskaya; Viktoria Adushkina; Arina Evsukova; Alexander Dubrovsky; Maria Tsoy; Valeria Telnova; Maria Manzhaeva; Alexander Dmitrenko; Valeria Krupnova; Jürgen Kurths
• Keywords: Sleep

In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation peripheral lymphatics, we demonstrate stronger effects photobiomodulation (PBM) brain's drainage system sleeping vs. awake animals. Using Pavlovian instrumental transfer probe 2-objects-location test, found that 10-day course PBM during sleep wakefulness promotes improved learning spatial memory mice. For first time, present technology for under electroencephalographic (EEG) control incorporates modern state art facilities optoelectronics biopotential detection can be built relatively cheap commercially available components. These findings open a new niche development smart technologies phototherapy diseases sleep.