Combined photoacoustic and ultrasound biomicroscopy

Diagnostic Imaging Microscopy Optics and Photonics Light Microcirculation Acoustics Equipment Design 01 natural sciences Carbon Fingers Oscillometry 0103 physical sciences Image Processing, Computer-Assisted Microscopy, Electron, Scanning Humans Ultrasonics Ultrasonography
DOI: 10.1364/oe.17.022041 Publication Date: 2009-11-17T17:50:28Z
ABSTRACT
We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique light-delivery system. The system is capable of 20 ultrasound frames per second and slower photoacoustic frame rates limited by laser pulse-repetition rates. Laser and ultrasound pulses are interlaced for co-registration of photoacoustic and ultrasound images. In vivo imaging of a human finger permits ultrasonic visualization of vessel structures and speckle changes indicative of blood flow, while overlaid photoacoustic images highlight some small vessels that are not clear from the ultrasound scan. Photoacoustic images provide optical absorption contrast co-registered in the structural and blood-flow context of ultrasound with high-spatial resolution and may prove important for clinical diagnostics and basic science of the microvasculature.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (10)
CITATIONS (73)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....