Combined photoacoustic and ultrasound biomicroscopy

• DOI: 10.1364/oe.17.022041
• Publication Date: 2009-11-17T17:50:28Z
• Authors: Tyler Harrison; Janaka C. Ranasin...; Huihong Lu; Kory Mathewson; Andrew Walsh; Roger J. Zemp
• Keywords: Photoacoustic Doppler effect; Photoacoustic effect

We report on the development of an imaging system capable combined ultrasound and photoacoustic based a fast-scanning single-element 25-MHz transducer unique light-delivery system. The is 20 frames per second slower frame rates limited by laser pulse-repetition rates. Laser pulses are interlaced for co-registration images. In vivo human finger permits ultrasonic visualization vessel structures speckle changes indicative blood flow, while overlaid images highlight some small vessels that not clear from scan. Photoacoustic provide optical absorption contrast co-registered in structural blood-flow context with high-spatial resolution may prove important clinical diagnostics basic science microvasculature.