Combined photoacoustic and ultrasound biomicroscopy
Diagnostic Imaging
Microscopy
Optics and Photonics
Light
Microcirculation
Acoustics
Equipment Design
01 natural sciences
Carbon
Fingers
Oscillometry
0103 physical sciences
Image Processing, Computer-Assisted
Microscopy, Electron, Scanning
Humans
Ultrasonics
Ultrasonography
DOI:
10.1364/oe.17.022041
Publication Date:
2009-11-17T17:50:28Z
AUTHORS (6)
ABSTRACT
We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique light-delivery system. The system is capable of 20 ultrasound frames per second and slower photoacoustic frame rates limited by laser pulse-repetition rates. Laser and ultrasound pulses are interlaced for co-registration of photoacoustic and ultrasound images. In vivo imaging of a human finger permits ultrasonic visualization of vessel structures and speckle changes indicative of blood flow, while overlaid photoacoustic images highlight some small vessels that are not clear from the ultrasound scan. Photoacoustic images provide optical absorption contrast co-registered in the structural and blood-flow context of ultrasound with high-spatial resolution and may prove important for clinical diagnostics and basic science of the microvasculature.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (10)
CITATIONS (73)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....