Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow

• DOI: 10.1364/oe.392993
• Publication Date: 2020-05-11T06:00:07Z
• Authors: Tiange Wu; Junfeng Shen; Zongwen Li; Tingting Zou; Wei Xin; Fei Xing; Fang Zhang; Zhongsheng Man; Shenggui Fu
• Keywords: Peristaltic pump

Highly sensitive, real-time and label-free sensing of liquid flow in microfluidic environments remains challenging. Here, by growing high-quality graphene directly on a glass substrate, we designed microfluidic-integrated graphene-based sensor (GFS) capable detecting complex, weak, transient velocity pressure signals environment. This device was used to study weak flows, especially blood flow, which is closely related heart artery functions. By simulating cardiac peristalsis arterial using peristaltic pumps systems, monitored simulated flow. ultrasensitive accurately detected limit as low 0.7 mm/s, pumping frequency range 0.04 Hz 2.5 Hz, from 0.6 kPa 14 kPa. measuring the velocities pressures, pathological were distinguished captured corresponding or can reflect vascular occlusion may be for monitoring patients’ basic vital signs their provide possible new method care critically ill patients.