Compact laser-diode-based optoacoustic mesoscopy

• DOI: 10.1364/ol.532067
• Publication Date: 2024-10-30T16:01:19Z
• Authors: Xiang Liu; Weiye Li; Yu-Hang Liu; Héctor Estrada; Daniel Razansky
• Keywords: 0301 basic medicine; 03 medical and health sciences

Short-pulsed solid-state lasers (SSLs) are the most commonly employed light sources in optoacoustic imaging applications. However, their bulky size hinders compact and portable system implementations. Here we developed a laser diode (LD)-based mesoscopy (CoLD-OAM) scanner that employs fiber-coupled source with 46 × 43 11 mm dimensions. CoLD-OAM features scalable excitation pulse width 30–200 ns range, high energies up to 6 µJ, excellent pulse-to-pulse energy stability of 0.42%. Real-time human wrist has been demonstrated system, achieving image quality similar SSL-based systems. These advancements facilitate development systems strong clinical translation commercialization potential.