Systematic Characterization of Myocardial Inflammation, Repair, and Remodeling in a Mouse Model of Reperfused Myocardial Infarction

• DOI: 10.1369/0022155413493912
• Publication Date: 2013-05-29T06:18:46Z
• Authors: Panagiota Christia; Marcin Bujak; Carlos Gonzalez-Q...; Wei Chen; Marcin Dobaczewski; Anilkumar Reddy; Nikolaos G. Frang...
• Keywords: Ventricular remodeling; End-diastolic volume

Mouse models of myocardial infarction are essential tools for the study cardiac injury, repair, and remodeling. Our current investigation establishes a systematic approach quantitative evaluation inflammatory reparative response, function, geometry in mouse model reperfused infarction. Reperfused infarcts exhibited marked induction cytokines that peaked after 6 hr reperfusion. In infarcted heart, scar contraction chamber dilation continued at least 28 days reperfusion; infarct maturation was associated with thinning scar, accompanied by volume loss rapid clearance cellular elements. Echocardiographic measurements end-diastolic dimensions correlated well morphometric assessment dilative remodeling perfusion-fixed hearts. Hemodynamic monitoring used to quantitatively assess systolic diastolic function; severity dysfunction following cardiomyocyte hypertrophy collagen content. Expression molecular mediators inflammation infiltration needs be investigated during first 72 hr, whereas requires measurement geometric parameters four weeks acute event. Rapid initiation resolution accelerated maturation, extensive important characteristics healing mice.