Morphology of Schwann Cell Processes Supports Renal Sympathetic Nerve Terminals With Local Distribution of Adrenoceptors

• DOI: 10.1369/00221554221106812
• Publication Date: 2022-06-16T13:53:51Z
• Authors: Seishi Maeda; Yusuke Minato; Sachi Kuwahara-Otani; Hiroki Yamanaka; Mitsuyo Maeda; Yosky Kataoka; Hideshi Yagi
• Keywords: Free nerve ending; Adrenergic Neurons

Nerves in the renal parenchyma comprise sympathetic nerves that act on arteries and tubules to decrease blood flow increase primary urine reabsorption, respectively. Synaptic vesicles release neurotransmitters activate their effector tissues. However, mechanisms by which exert individual responses cells remain unknown. Here, we investigated spatial molecular compositional associations of Schwann (SC) supporting nerve terminals male rats. The vascular smooth muscle (SMCs) enclosed SC processes were exposed through windows facing effectors with presynaptic specializations. We found adrenergic receptors (ARs) α2A, α2C, β2 localized SMC basal side tubules, where attached, whereas other subtypes ARs distributed glomerular luminal side, norepinephrine released from endings may have indirect access ARs. In addition, integrins α4 β1 coexpressed terminals. Thus, could contact via a structure, covered processes, suitable for intensive directional into blood, rather than specialized structures postsynaptic region.