Osteopontin Expression in Normal Skin and Non-melanoma Skin Tumors

• DOI: 10.1369/jhc.7a7325.2007
• Publication Date: 2007-10-16T00:44:52Z
• Authors: Pi-Ling Chang; Louie Harkins; Yu-Hua Hsieh; Patricia Hicks; Kraisorn Sappayat...; Somchai Yodsanga; Somporn Swasdison; Ann F. Chambers; Craig A. Elmets; Kang-Jey Ho
• Keywords: Osteopontin; Matricellular protein; Actinic keratosis; Human skin

Osteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression elevated in many types of cancer and has been shown to facilitate tumorigenesis vivo. To understand the role OPN human skin cancer, this study designed determine whether expressed premalignant [solar/actinic keratosis (AK)] malignant lesions such as squamous cell carcinomas (SCC) basal (BCC), well normal exposed or not sunlight. Immunohistochemical analyses showed that SCC (20/20 cases) AK (16/16 cases), which are precursors SCC, but absent minimally solid BCC (17 cases). However, positive staining for was observed those manifest differentiation toward epidermal appendages keratotic BCC. In sunlight-exposed skin, layer, contrast sunlight, more prominent spinous layer with increasing intensity granular layer. Additionally, hair follicles, sebaceous glands, sweat glands skin. conclusion, these data suggest associated keratinocyte it have metastatic potential,