Correction: Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

• DOI: 10.1371/annotation/3aa92c3d-b6dd-4c6e-8cee-9587ce80a9c9
• Publication Date: 2014-02-26T16:14:58Z
• Authors: Erin H. Graf; Matthew J. Pace; Bennett A. Peterson; Lindsay J. Lynch; Steve B. Chukwulebe; Angela M. Mexas; Farida Shaheen; Jeffrey N. Martin; Steven G. Deeks; Mark Connors; Stephen A. Migueles; Una O’Doherty
• Keywords: CTL*

Resting CD4+ T cells infected with HIV persist in the presence of suppressive anti-viral therapy (ART) and are barriers to a cure.One potential curative approach, therapeutic vaccination, is fueled by recognition ability subset elite controllers (EC) control virus without due robust anti-HIV immune responses.Controllers have low levels integrated DNA replication competent virus, suggesting small reservoir.As our recent data indicates some reservoir can produce proteins (termed GPR for Gag-positive cells), we hypothesized that fraction HIV-expressing resting could be efficiently targeted cleared individuals who via cytotoxic lymphocytes (CTL).To test this examined if superinfected from EC express Gag producing infectious susceptibility these CTL.We found expressed were autologous CD8+ EC. Importantly, extent CTL clearance vitro assay correlates vivo size population expressing exists patients well controlled on therapy.