Correction: The Role of α7Nicotinic Acetylcholine Receptor in Modulation of Heart Rate Dynamics in Endotoxemic Rats

• DOI: 10.1371/annotation/4103a8bf-a523-4db9-91f2-d974b175aafa
• Publication Date: 2013-12-30T17:25:20Z
• Authors: Roham Mazloom; Golnar Eftekhari; Maryam Rahimi; Vahid Khori; Sohrab Hajizadeh; Ahmad R. Dehpour; Ali R. Mani
• Keywords: Science; Q; R; Medicine; Correction

Previous reports have indicated that artificial stimulation of the vagus nerve reduces systemic inflammation in experimental models sepsis.This phenomenon is a part broader cholinergic anti-inflammatory pathway which activates to modulate through activation alpha7 nicotinic acetylcholine receptors (α7nACHR).Heart rate variability represents complex interplay between autonomic nervous system and cardiac pacemaker cells.Reduced heart increased cycle regularity hallmark clinical conditions are associated with (e.g.endotoxemia sepsis).The present study was aimed assess role α7nACHR modulation dynamics during inflammation.Systemic induced by injection endotoxin (lipopolysaccharide) rats.Electrocardiogram body temperature were recorded conscious animals using telemetric system.Linear non-linear indices (e.g.sample entropy fractal-like temporal structure) assessed.RT-PCR immunohistochemistry studies showed expressed rat atrium mainly localized at endothelial layer.Systemic administration an antagonist (methyllycaconitine) did not show significant effect on or naïve rats.However, blockade could further reduce elicit febrile response endotoxemic rats.Pre-treatment agonist (PHA-543613) unable rats but prevent within 24 h experiment.Neither methyllycaconitine nor PHA-543613 affect beating isolated perfused hearts taken from control rats.Based our observations we suggest tonic for inflammation.