Correction: Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells

• DOI: 10.1371/annotation/6382d059-925d-4af7-b6f2-3669fc68ddfa
• Publication Date: 2013-06-14T17:47:28Z
• Authors: Amy E. L. Stone; Silvia Giugliano; Gretja Schnell; Linling Cheng; Katelyn F. Leahy; Lucy Golden-Mason; Michael Gale; Hugo R. Rosen
• Keywords: Plasmacytoid dendritic cell

Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell in the defense against viruses.Through pattern recognition receptors (PRRs), these cells detect viral pathogen associated molecular patterns (PAMPs) and initiate an Interferon (IFN) response.pDCs produce antiviral IFNs including well-studied Type I more recently described III.Recent genome wide association studies (GWAS) have implicated III HCV clearance.We examined IFN response induced pDC line ex vivo human pDCs by region of referred to as PAMP.This RNA has been shown previously be immunogenic hepatocytes, whereas conserved X-region is not.We show that PAMP, pDC-GEN2.2cells upregulate secrete (in addition I) PRR genes proteins.We also demonstrate this dependent on RIG-I-like Receptors (RLRs) Toll-like (TLRs), challenging dogma RLRs are dispensable pDCs.The produced PAMP control replication vitro.These data recapitulated isolated from healthy donors.Together, our shows respond robustly make Interferons replication.This may novel therapeutic strategy for treatment HCV.