Correction: Nuclear Translocation of Jacob in Hippocampal Neurons after Stimuli Inducing Long-Term Potentiation but Not Long-Term Depression

• DOI: 10.1371/annotation/8d9dd14e-08f6-4f7e-b881-ba2839724e23
• Publication Date: 2011-03-10T22:16:01Z
• Authors: Thomas Behnisch; PingAn YuanXiang; Philipp Bethge; Suhel Parvez; Ying Chen; Jin Yu; Anna Karpova; Julietta U. Frey; Marina Mikhaylova; Michael R. Kreutz
• Keywords: Long-term depression; Depression

Background:In recent years a number of potential synapto-nuclear protein messengers have been characterized that are thought to be involved in plasticity-related gene expression, and the capacity importin-mediated activitydependent nuclear import.However, there is surprising paucity data showing import such proteins cellular models learning memory.Only recently it was found transcription factor cyclic AMP response element binding 2 (CREB2) transits nucleus during long-term depression (LTD), but not potentiation (LTP) synaptic transmission hippocampal primary neurons.Jacob another messenger couples NMDA-receptor-activity expression.We therefore aimed study whether Jacob accumulates physiological relevant activity-dependent plasticity.Methodology/Principal Findings: We analyzed dynamics Jacob's following induction NMDAreceptor dependent LTP or LTD at Schaffer collateral-CA1 synapses rat slices.Using time-lapse imaging neurons expressing Jacob-Green-Fluorescent-Protein we rapidly translocates from dendrites already tetanization period LTP, after LTD.Immunocytochemical stainings confirmed accumulation endogenous comparison apical LTD.Complementary findings were obtained NMDA-receptor chemical neurons.However, accordance with previous studies, high concentrations NMDA glycine as well specific activation extrasynaptic NMDA-receptors resembling pathological conditions induce an even more profound increase levels.Conclusions/Significance: Taken together, these suggest two major forms plasticity, LTD, elicit transition different albeit both cases importinmediated retrograde transport required.