Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

• DOI: 10.1371/journal.pbio.1000213
• Publication Date: 2009-10-05T22:01:55Z
• Authors: Zhihua Li; Insuk Lee; Emily Moradi; Nai-Jung Hung; Arlen W. Johnson; Edward M. Marcotte
• Keywords: ribosome biogenesis; Ribosomal protein

Gene networks are an efficient route for associating candidate genes with biological processes. Here, used to discover more than 15 new ribosomal subunit maturation, rRNA processing, and export from the nucleus.