ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

• DOI: 10.1371/journal.pbio.1000256
• Publication Date: 2009-12-14T22:59:54Z
• Authors: Ellen Markljung; Lin Jiang; Jacob D. Jaffe; Tarjei S. Mikkelsen; Ola Wallerman; Martin Larhammar; Xiaolan Zhang; Li Wang; Veronica Saenz-Vash; Andreas Gnirke; Anders M. Lindroth; Romain Barrés; Jie Yan; Sara Strömberg; Sachinandan De; Fredrik Pontén; Eric S. Lander; Steven A. Carr; Juleen R. Zierath; Klas Kullander; Claes Wadelius; Kerstin Lindblad-Toh; Göran Andersson; Göran Hjälm; Leif Andersson
• Keywords: C2C12; Chromatin immunoprecipitation; DNA binding site

This study identifies a previously uncharacterized protein, encoded by domesticated DNA transposon, called ZBED6 that regulates the expression of insulin-like growth factor 2 (IGF2) gene, and possibly numerous others, in all placental mammals including human.