Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

• DOI: 10.1371/journal.pbio.1000599
• Publication Date: 2011-03-16T19:08:05Z
• Authors: Jérôme Goudeau; Stéphanie Bellemin; Esther Toselli-Mo...; Mehrnaz Shamalnasab; Yiqun Chen; Hugo Aguilaniu
• Keywords: QH301-705.5; Recombinant Fusion Proteins; Fatty Acids; Longevity; Receptors, Cytoplasmic and Nuclear; Germ Cells; Animals; Biology (General); Caenorhabditis elegans; Caenorhabditis elegans Proteins; [SDV.BDD]Life Sciences [q-bio]/Development Biology; Stearoyl-CoA Desaturase; Research Article; Oleic Acid; Signal Transduction

Background Preventing germline stem cell proliferation extends lifespan in nematodes and flies. So far, studies on germline-longevity signaling have focused daf-16/FOXO daf-12/VDR. Here, we report NHR-80/HNF4, a nuclear receptor that specifically mediates longevity induced by depletion of the germ line through mechanism implicates fatty acid monodesaturation. Methods Findings nhr-80/HNF4 is animals lacking required for their extended longevity. Overexpressing increases germline-less animals. This extension can occur absence but requires presence DAF-12/VDR. We show desaturase, FAT-6/SCD1, key target NHR-80/HNF4 promotes desaturating stearic to oleic (OA). find OA must work concert promote Conclusions Taken together, our data indicate NHR-80 pathway participates line. identify fat-6 as essential downstream elements although other targets also be present. Thus, links desaturation ablation independent manner.