N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

• DOI: 10.1371/journal.pbio.1001073
• Publication Date: 2011-05-31T20:48:57Z
• Authors: Gabriella M. A. F...; Martin R. Pool; Colin J. Stirling
• Keywords: Protein Sorting Signals

Amino-terminal acetylation is probably the most common protein modification in eukaryotes with as many 50%-80% of proteins reportedly altered this way. Here we report a systematic analysis predicted N-terminal processing cytosolic versus those destined to be sorted secretory pathway. While were profoundly biased favour processing, found an equal and opposite bias against such for proteins. Mutations signal sequences that led their resulted mis-sorting cytosol manner was dependent upon machinery. Hence represents early determining step cellular sorting nascent polypeptides appears conserved across wide range species.