Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-β Antagonist, Controls Early Neuroectoderm Specification in Xenopus

• DOI: 10.1371/journal.pbio.1001286
• Publication Date: 2012-03-22T15:10:46Z
• Authors: Suhong Xu; Feng Cheng; Juan Liang; Wei Wu; Jian Zhang
• Keywords: Neuroectoderm; Chordin; Nodal signaling; Neural Development

Xenopus maternal Norrin, which activates Wnt signaling but inhibits TGF-β family molecules, is essential for neuroectoderm formation. Loss of inhibition in Norrin may contribute to the development Norrie disease.