Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation

• DOI: 10.1371/journal.pbio.1001320
• Publication Date: 2012-05-01T20:54:58Z
• Authors: Tomas Garzon-Muvdi; Paula Schiapparelli; Colette ap Rhys; Hugo Guerrero-Caz...; Christopher Smith; Deok-Ho Kim; Lyonell Kone; Harrison Farber; Danielle Y. Lee; Steven S. An; Andre Levchenko; Alfredo Quiñones-...
• Keywords: Male; QH301-705.5; Genetic Vectors; Green Fluorescent Proteins; Molecular Sequence Data; Fluorescent Antibody Technique; Mice; 03 medical and health sciences; Cell Movement; Animals; Humans; Amino Acid Sequence; Biology (General); Cloning, Molecular; Bumetanide; Cell Size; Focal Adhesions; 0303 health sciences; Brain Neoplasms; Glioma; 3. Good health; Gene Expression Regulation, Neoplastic; HEK293 Cells; Gene Knockdown Techniques; Mutagenesis, Site-Directed; Research Article

The ion transporter NKCC1 determines brain tumor cell migration by regulating the interplay between adhesion and growth factor signaling, is a potential therapeutic target to treat cancer.