An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

• DOI: 10.1371/journal.pbio.1001350
• Publication Date: 2012-06-27T14:53:14Z
• Authors: Deepak P. Srivastava; Kevin M. Woolfrey; Kelly A. Jones; Charles T. Anderson; Katharine R. Smith; Theron A. Russell; Hyerin Lee; Marina V. Yasvoina; David L. Wokosin; P. Hande Ozdinler; Gordon M. G. Shep...; Peter Penzes
• Keywords: Dendrite (mathematics); Apical dendrite

Epac2 disruption impairs basal (but not apical) dendrite complexity in cortical neurons, and an autism-associated mutation implicates a Ras/Epac2 signaling pathway the active maintenance of dendritic arbors.