Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

• DOI: 10.1371/journal.pbio.1001721
• Publication Date: 2013-11-26T21:57:28Z
• Authors: Shoujun Huang; Zhao Zhang; Chunxia Zhang; Xiangdong Lv; Xiudeng Zheng; Zhenping Chen; Liwei Sun; Hailong Wang; Yuanxiang Zhu; Jing Zhang; Shuyan Yang; Yi Lu; Qinmiao Sun; Yi Tao; Feng Liu; Yun Zhao; Dahua Chen
• Keywords: Smoothened; Patched; GLI1

Protein turnover of Patched, the Hedgehog receptor and key negative regulator signaling, is controlled by ubiquitin E3 ligase, Smurf, in a manner that depends on activation signal transducer, Smoothened.