A Novel Nodal Enhancer Dependent on Pluripotency Factors and Smad2/3 Signaling Conditions a Regulatory Switch During Epiblast Maturation

• DOI: 10.1371/journal.pbio.1001890
• Publication Date: 2014-06-24T20:19:03Z
• Authors: Costis Papanayotou; Ataaillah Benhaddou; Anne Camus; Aitana Perea-Gomez; Alice Jouneau; Valérie Mezger; Francina Langa; Sascha Ott; Délara Sabéran-Dj...; Jérôme Collignon
• Keywords: Nodal signaling; Epiblast

HBE, a newly discovered enhancer element, mediates the influence of pluripotency factors and Activin/Nodal signaling on early Nodal expression in mouse embryo, controls activation later-acting enhancers.