Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

2. Zero hunger Mardivirus QH301-705.5 Marek Disease Animals Marek Disease Vaccines Biology (General) Selection, Genetic Chickens Research Article Virus Shedding 3. Good health
DOI: 10.1371/journal.pbio.1002198 Publication Date: 2015-07-27T17:44:05Z
ABSTRACT
Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines keep hosts alive but still allow transmission could thus very strains to circulate in a population. Here we show experimentally immunization chickens against Marek's disease virus enhances fitness strains, making it possible for hyperpathogenic transmit. Immunity elicited by direct vaccination or maternal prolongs survival does not prevent infection, viral replication transmission, extending infectious periods otherwise too persist. Our data anti-disease do can create conditions promote emergence pathogen cause severe unvaccinated hosts.
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