Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

• DOI: 10.1371/journal.pbio.2005264
• Publication Date: 2018-10-17T17:28:51Z
• Authors: Andrew D. Greenhalgh; Juan G. Zarruk; Luke M. Healy; Sam J. Baskar Jes...; Priya Jhelum; Christopher K. Sa...; Albert Formanek; Matthew V. Russo; Jack P. Antel; Dorian B. McGavern; Barry W. McColl; Samuel David
• Keywords: Monocyte

Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after are beginning to be uncovered. Here, we show evidence that MDMs directly communicate with one another differentially modulate each other’s functions. Importantly, microglia-mediated phagocytosis inflammation suppressed by infiltrating macrophages. In the context of spinal cord (SCI), preventing such communication increases microglial activation worsens functional recovery. We suggest entering CNS provide a regulatory mechanism controls acute long-term inflammation, which may drive damage in variety conditions.