EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis

• DOI: 10.1371/journal.pbio.3000680
• Publication Date: 2020-11-30T19:27:00Z
• Authors: Manon Gervais; Gwenaël Labouèbe; Alexandre Picard; Bernard Thorens; Sophie Croizier
• Keywords: Proopiomelanocortin; Kainate receptor

Proopiomelanocortin (POMC) neurons are major regulators of energy balance and glucose homeostasis. In addition to being regulated by hormones nutrients, POMC controlled glutamatergic input originating from multiple brain regions. However, the factors involved in formation inputs how they contribute bodily functions remain largely unknown. Here, we show that during development inputs, exhibit enriched expression Efnb1 (EphrinB1) Efnb2 (EphrinB2) genes, which known control excitatory synapse formation. vivo loss POMC-expressing progenitors decreases amount associated with a reduced number α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) N-methyl-D-aspartate (NMDA) receptor subunits excitability these cells. We found mice lacking display impaired tolerance due blunted vagus nerve activity decreased insulin secretion. despite showed no deregulation secretion only mild alterations feeding behavior gluconeogenesis. Collectively, our data demonstrate role ephrins controlling into an isotype-specific on regulation homeostasis feeding.