Hypoxia extends lifespan and neurological function in a mouse model of aging

• DOI: 10.1371/journal.pbio.3002117
• Publication Date: 2023-05-23T17:29:58Z
• Authors: Robert S. Rogers; Hong Wang; Timothy J. Durham; Jonathan A. Stefely; Norah A. Owiti; Andrew L. Markhard; Lev Sandler; Tsz-Leung To; Vamsi K. Mootha
• Keywords: Hypoxia; Senescence; Model Organism

There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence cultured cells and extends lifespan yeast, nematodes, fruit flies. Here, we asked whether chronic beneficial mammalian aging. We utilized Ercc1 Δ/- mouse model accelerated aging given these mice are born developmentally normal but exhibit anatomic, physiological, biochemical features across multiple organs. Importantly, they a shortened extended by dietary restriction, most potent intervention many organisms. report 11% oxygen commenced at 4 weeks age 50% neurological debility mice. did not impact food intake significantly affect markers DNA damage or senescence, suggesting simply alleviate proximal effects mutation, rather acted downstream via unknown mechanisms. To best our knowledge, this first study to demonstrate “oxygen restriction” can