Developing a Molecular Roadmap of Drug-Food Interactions

• DOI: 10.1371/journal.pcbi.1004048
• Publication Date: 2015-02-10T18:45:30Z
• Authors: Kasper Jensen; Yueqiong Ni; Gianni Panagiotou; Irene Kouskoumvekaki
• Keywords: DrugBank; Interactome; Pharmacodynamics; Drug repositioning

Recent research has demonstrated that consumption of food -especially fruits and vegetables- can alter the effects drugs by interfering either with their pharmacokinetic or pharmacodynamic processes. Despite recognition such drug-food associations as an important element for successful therapeutic interventions, a systematic approach identifying, predicting preventing potential interactions between marketed novel is not yet available. The overall objective this work was to sketch comprehensive picture interference ∼ 4,000 dietary components present in ∼1800 plant-based foods pharmacokinetics pharmacodynamics processes medicine, purpose elucidating molecular mechanisms involved. By employing systems chemical biology integrates data from scientific literature online databases, we gained global view diet molecules drug targets, metabolic enzymes, transporters carriers currently deposited DrugBank. Moreover, identified disease areas targets are most prone negative interactions, showcasing platform making recommendations relation should be avoided under certain medications. Lastly, investigating correlation gene expression signatures were able generate completely drug-diet interactome map.