Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy

• DOI: 10.1371/journal.pcbi.1009081
• Publication Date: 2021-06-23T20:07:33Z
• Authors: Sahar Jafari Nivl...; M. Soltani; João Carvalho; Rui Travasso; Mohammad Reza Sal...; Ebrahim Shirani
• Keywords: Vascular Endothelial Growth Factor A; 0301 basic medicine; Systems Analysis; Neovascularization, Pathologic; QH301-705.5; Computational Biology; Models, Biological; 3. Good health; 03 medical and health sciences; Neoplasms; Animals; Humans; Tumor Hypoxia; Computer Simulation; Neoplasm Invasiveness; Molecular Targeted Therapy; Biology (General); Algorithms; Research Article; Cell Proliferation; Signal Transduction

The dynamics of tumor growth and associated events cover multiple time spatial scales, generally including extracellular, cellular intracellular modifications. main goal this study is to model the biological physical behavior evolution in presence normal healthy tissue, considering a variety involved process. These include hyper hypoactivation signaling pathways during growth, vessels' intratumoral vascularization competition cancer cells with host tissue. work addresses two distinctive phases development-the avascular vascular phases-and each stage cases are considered-with without cells. rate increases considerably as closed vessel loops (anastomoses) form around resulting from induced vascularization. When taking into account tissue tumor, results show that between leads formation hypoxic core within relatively short period time. Moreover, dense network formed throughout entire lesion sign high malignancy grade, which consistent reported experimental data for several types solid carcinomas. In comparison other mathematical models development, we introduce multiscale simulation interactions cell consequence activation oncogenes deactivation gene cell. Simulating therapy blocks relevant prevention further an expressive decrease its size (82% simulation).