Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

• DOI: 10.1371/journal.pgen.1000378
• Publication Date: 2009-02-13T00:17:33Z
• Authors: Arne S. Schaefer; Gesa M. Richter; Birte Groessner-S...; Barbara Noack; Michael Nothnagel; Nour-Eddine El Mo...; Bruno G. Loos; Søren Jepsen; Stefan Schreiber
• Keywords: Linkage Disequilibrium; Genetic Association

Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors characterized by chronic inflammatory process. In candidate-gene association study, we identify an of genetic susceptibility locus shared both diseases. We confirm the known two neighboring linkage disequilibrium regions on human chromosome 9p21.3 CHD show additional strong these loci aggressive For lead SNP main region, rs1333048, odds ratio autosomal-recessive mode inheritance is 1.99 (95% confidence interval 1.33–2.94; P = 6.9×10−4) for generalized periodontitis, 1.72 (1.06–2.76; 2.6×10−2) localized The map to sequence large antisense noncoding RNA ANRIL, which partly overlaps regulatory coding sequences CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent periodontitis haplotypes. Our study demonstrates that genetically related at least one locus, possibly involved in ANRIL activity diabetes variants within this region. Elucidation interplay transcript their involvement increased interactive promises new insight into underlying pathogenic mechanisms complex common