Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

• DOI: 10.1371/journal.pgen.1001300
• Publication Date: 2011-02-11T00:16:21Z
• Authors: Guillaume Lettre; Cameron D. Palmer; Taylor Young; Kenechi G. Ejebe; Hooman Allayee; Emelia J. Benjamin; Franklyn Bennett; Donald W. Bowden; Aravinda Chakravarti; Al Dreisbach; Deborah N. Farlow; Aaron R. Folsom; Myriam Fornage; Terrence Forrester; Ervin Fox; Christopher A. Ha...; Jaana Hartiala; Tamara B. Harris; Stanley L. Hazen; Susan R. Heckbert; Brian E. Henderson; Joel N. Hirschhorn; Brendan J. Keating; Stephen B. Kritch...; Emma Larkin; Mingyao Li; Megan E. Rudock; Colin A. McKenzie; James B. Meigs; Yang A. Meng; Tom H. Mosley; Anne B. Newman; Christopher H. Ne...; Dina N. Paltoo; George J. Papanic...; Nick Patterson; Wendy S. Post; Bruce M. Psaty; Atif N. Qasim; Liming Qu; Daniel J. Rader; Susan Redline; Muredach P. Reilly; Alexander P. Reiner; Stephen S. Rich; Jerome I. Rotter; Yongmei Liu; Peter Shrader; David S. Siscovick; W. H. Wilson Tang; Herman A. Taylor; Russell P. Tracy; Ramachandran S. V...; Kevin M. Waters; Rainford Wilks; James G. Wilson; Richard R. Fabsitz; Stacey B. Gabriel; Sekar Kathiresan; Eric Boerwinkle
• Keywords: Genome-wide Association Study; Linkage Disequilibrium; Genetic Association; Genetic genealogy; SNP; Population stratification

Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- HDL-cholesterol (LDL-C HDL-C), hypertension, smoking, type-2 diabetes) individuals ancestry, we performed a genome-wide association study (GWAS) 8,090 Americans from five population-based cohorts. We replicated 17 loci previously or Caucasians. For these regions (CHD: CDKN2A/CDKN2B; HDL-C: FADS1-3, PLTP, LPL, ABCA1), could leverage distinct linkage disequilibrium (LD) patterns to DNA more strongly phenotypes than reported index SNPs found Caucasian populations. also developed new approach for testing admixed populations that uses allelic local ancestry variation. Using this method, discovered several would have been missed using basic global information only. Our conclusions suggest no major uniquely explain high prevalence project has resources methods address both admixture- SNP-association maximize power discovery even larger African-American consortia.