Telomere DNA Deficiency Is Associated with Development of Human Embryonic Aneuploidy

• DOI: 10.1371/journal.pgen.1002161
• Publication Date: 2011-06-30T17:07:05Z
• Authors: Nathan R. Treff; Jing Su; Deanne Taylor; Richard T. Scott
• Keywords: Polar body

Aneuploidy represents the most prevalent form of genetic instability found in human embryos and is leading cause miscarriage developmental delay newborns. Telomere DNA deficiency associated with genomic somatic cells may play a role development aneuploidy commonly female germ embryos. To test this hypothesis, we developed method capable quantifying telomere parallel 24-chromosome screening from same oocyte or embryo biopsy. Aneuploid polar bodies possessed significantly less than euploid sibling oocytes (−3.07 fold, P = 0.016). This indicates that are prone to during meiosis. embryonic also at cleavage stage (−2.60 0.002) but not blastocyst (−1.18 0.340). The lack significant difference was be due normalization between embryogenesis arrest short telomeres. Heterogeneity length within provide an opportunity improve treatment infertility through telomere-based selection reproductive competence.