Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

• DOI: 10.1371/journal.pgen.1002292
• Publication Date: 2011-09-29T17:40:19Z
• Authors: Carsten A. Böger; Mathias Gorski; Man Li; Michael M. Hoffmann; Chunmei Huang; Qiong Yang; Alexander Teumer; Vera Krane; Conall M. O'Seaghdha; Zoltán Kutalik; H.-Erich Wichmann; Thomas Haak; Eva Boes; Stefan Coassin; Josef Coresh; Barbara Kollerits; Margot Haun; Bernhard Paulweber; Anna Köttgen; Guo Li; Michael G. Shlipak; Neil Powe; Shih-Jen Hwang; Abbas Dehghan; Fernando Rivadeneira; André Uitterlinden; Albert Hofman; Jacques S. Beckmann; Bernhard K. Krämer; Jacqueline Witteman; Murielle Bochud; David Siscovick; Rainer Rettig; Florian Kronenberg; Christoph Wanner; Ravi I. Thadhani; Iris M. Heid; Caroline S. Fox; W. H. Kao
• Keywords: Genome-wide Association Study; Genetic Association

Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but associations these single nucleotide polymorphisms (SNPs) incident CKD or ESRD are unknown. We thus investigated with 26,308 individuals European ancestry free at baseline drawn from eight population-based cohorts followed median 7.2 years (including 2,122 cases defined as <60ml/min/1.73m2 follow-up) four case-control subjects (3,775 cases, 4,577 controls). SNPs 11 (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, GCKR) were associated CKD; p-values ranged p = 4.1e-9 UMOD 0.03 GCKR. After adjusting eGFR, six remained significantly STC1). (OR 0.92, 0.04) GCKR 0.93, 0.03) nominally ESRD. In summary, majority eGFR-related either show strong trend towards CKD, have modest descent. Additional work is required characterize determinants different stages progression.