abd-A Regulation by the iab-8 Noncoding RNA

• DOI: 10.1371/journal.pgen.1002720
• Publication Date: 2012-05-24T21:04:36Z
• Authors: Maheshwar Gummalla; Robert K. Maeda; Javier J. Castro ...; Henrik Gyurkovics; Swetha Singari; Kevin A. Edwards; François Karch; Welcome Bender
• Keywords: Ectopic expression

The homeotic genes in Drosophila melanogaster are aligned on the chromosome order of body segments that they affect. affecting more posterior repress anterior genes. This dominance rule must be qualified case abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression abd-A epidermis eighth abdominal segment, but not central nervous system. Repression these neuronal cells is accomplished a 92 kb noncoding RNA. "iab-8 RNA" produces micro RNA to abd-A, also has second, redundant mechanism acts only "in cis." Transcriptional interference with promoter most likely mechanism.