Asymmetric Division and Differential Gene Expression during a Bacterial Developmental Program Requires DivIVA

• DOI: 10.1371/journal.pgen.1004526
• Publication Date: 2014-08-07T18:07:57Z
• Authors: Prahathees Eswara...; Peter W. Winter; Peter Wawrzusin; Andrew G. York; Hari Shroff; Kumaran S. Ramamu...
• Keywords: Asymmetric cell division; Cell polarity

Sporulation in the bacterium Bacillus subtilis is a developmental program which progenitor cell differentiates into two different types, smaller of eventually becomes dormant called spore. The process begins with an asymmetric division event, followed by activation transcription factor, σF, specifically cell. Here, we show that structural protein DivIVA localizes to polar septum during sporulation and required for compartment-specific σF. Both events are known require SpoIIE, also septum. We copurifies SpoIIE may anchor briefly assembling before subsequently released forespore membrane recaptured at Finally, using super-resolution microscopy, demonstrate ultimately display biased localization on side faces compartment σF activated.