Integrating sex-bias into studies of archaic introgression on chromosome X

• DOI: 10.1371/journal.pgen.1010399
• Publication Date: 2023-08-14T17:30:17Z
• Authors: Elizabeth T. Chevy; Emilia Huerta-Sán...; Sohini Ramachandran
• Keywords: Introgression

Evidence of interbreeding between archaic hominins and humans comes from methods that infer the locations segments haplotypes, or ‘archaic coverage’ using genomes people living today. As more estimates coverage have emerged, it has become clear most this is found on autosomes— very little retained chromosome X. Here, we summarize published autosomes X extant human samples. We find average 7 times than X, identify broad continental patterns in ratio: greatest European samples, least South Asian also perform extensive simulation studies to investigate how amount coverage, lengths rates purging are affected by sex-bias caused an unequal sex ratio within introgressors. Our results generally confirm that, with increasing male sex-bias, less Ours first study explicitly model such its potential role creating dearth