Urinary interleukins (IL)-6 and IL-10 in schoolchildren from an area with low prevalence of Schistosoma haematobium infections in coastal Kenya

• DOI: 10.1371/journal.pgph.0001726
• Publication Date: 2023-04-05T17:38:01Z
• Authors: Kariuki H. Njaanake; Job Omondi; Irene Mwangi; Walter G. Jaoko; Omu Anzala
• Keywords: Interleukin 1β

Urinary cytokines are gaining traction as tools for assessing morbidity in infectious and non-infectious inflammatory diseases of the urogenital tract. However, little is known about potential these due to S. haematobium infections. Factors that may influence urinary cytokine levels markers also remain unknown. Therefore objective present study was assess how interleukins (IL-) 6 10 associated with gender, age, infections, haematuria tract pathology and; 2) effects urine storage temperatures on cytokines. This a cross-sectional 2018 involving 245 children aged 5-12 years from endemic area coastal Kenya. The were examined morbidity, (IL-6 IL-10). Urine specimens stored at -20°C, 4°C or 25°C 14 days before being assayed IL6 IL-10 using ELISA. overall prevalence pathology, haematuria, IL-6 36.3%, 35.8%, 14.8%, 59.4% 80.5%, respectively. There significant associations between IL-6, but not IL-10, infection (p = 0.045, 0.011 0.005, respectively) sex ultrasound-detectable pathology. differences -20°C those (p<0.001) and, (p<0.001). children's infections haematuria. both morbidity. Both sensitive temperatures.