Factors associated with viral load re-suppression after enhanced adherence counseling among people living with HIV with an initial high viral load result in selected Nigerian states

• DOI: 10.1371/journal.pgph.0002876
• Publication Date: 2024-11-22T18:32:07Z
• Authors: Gbenga Benjamin O...; Mukhtar Ijaiya; Ejike Okwor; Babafemi Dare; Franklin Emerenini; Remi Oladigbolu; Prince Anyanwu; Adewale Akinjeji; Kate Brickson; Jennifer Zech; Yemisi Ogundare; Emmanuel Atuma; Molly Strachan; Ruby Fayorsey; Kelly Curran
• Keywords: Public aspects of medicine; RA1-1270; Research Article

The WHO recommends monitoring viral load (VL) to gauge ART efficacy among People Living with HIV (PLHIV). Low suppression rates persist in low- and middle-income countries due poor adherence. Enhanced Adherence Counseling (EAC) aims improve adherence treatment outcomes. This study, part of the Reaching Impact Saturation Epidemic Control (RISE) project Nigeria, analyzes factors affecting re-suppression post-EAC. It inform clinical decisions PLHIV health outcomes country. was a retrospective analysis de-identified client-level dataset unsuppressed VL clients who were current on at end June 2022 subsequently enrolled EAC program. A log-binomial regression model used report crude adjusted risk ratio 95% Confidence Intervals (95% CI) p-value 0.05 determine association between characteristics post-EAC RISE program (July 2021 2022). total 1607 initial high completed included this out which 1454 (91%) virally suppressed. median time completion 8 weeks for post test weeks. Following EAC, 10–19 years age band 10% more likely be re-suppressed (ARR: 1.10; CI 1.01 1.19). In addition, there 50% reduced likelihood second-line regimens compared first-line 0.50; 0.41 0.62). Findings show that Age regimen significant predictors VLS. More targeted outreach amongst ages 10 above is necessary ensure better VLS within these groups.