Elective and nonelective cesarean section and obesity among young adult male offspring: A Swedish population–based cohort study

• DOI: 10.1371/journal.pmed.1002996
• Publication Date: 2019-12-06T13:22:58Z
• Authors: Viktor H. Ahlqvist; Margareta Persson; Cecilia Magnusson; Daniel Berglind
• Keywords: Adult; Male; Pediatric Obesity; Adolescent; Body Mass Index; Cohort Studies; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Gynaecology, Obstetrics and Reproductive Medicine; Birth Weight; Humans; Gynekologi, obstetrik och reproduktionsmedicin; Sweden; 2. Zero hunger; Cesarean Section; R; Overweight; 3. Good health; Diabetes, Gestational; Medicine; Female; Research Article; Maternal Age

Previous studies have suggested that cesarean section (CS) is associated with offspring overweight and obesity. However, few been able to differentiate between elective nonelective CS, which may differ in their maternal risk profile biological pathway. Therefore, we aimed examine the association differentiated forms of delivery CS obesity young adulthood.Using Swedish population registers, a cohort 97,291 males born 1982 1987 were followed from birth until conscription (median 18 years age) if they conscripted before 2006. At conscription, weight height measured transformed World Health Organization categories body mass index (BMI). Maternal infant data obtained Medical Birth Register. Associations evaluated using multinomial linear regressions. Furthermore, series sensitivity analyses conducted, including fixed-effects regressions account for confounders shared full brothers. The mothers conscripts on average 28.5 (standard deviation 4.9) old at had prepregnancy BMI 21.9 3.0), 41.5% least one parent university-level education. Out observed, 4.9% obese (BMI ≥ 30) conscription. prevalence varied slightly vaginal delivery, (4.9%, 5.5%, 5.6%, respectively), whereas seemed be consistent across modes delivery. We found no evidence an or adulthood (relative ratio 0.96, confidence interval 95% 0.83-1.10, p = 0.532 relative 1.02, 0.88-1.18, 0.826, respectively) as compared after accounting BMI, diabetes hypertension smoking, parity, parental education, age gestational age, standardized according preeclampsia. any form 25) Sibling analysis several did not alter our findings. main limitations study all available measures anthropometry and/or important (42% retained) only included male population.We when prenatal factors. This suggests there clinically relevant development Further large-scale are warranted adult offspring.Registered observational ClinicalTrials.gov Identifier: NCT03918044.