Gene Expression Signatures of Radiation Response Are Specific, Durable and Accurate in Mice and Humans

• DOI: 10.1371/journal.pone.0001912
• Publication Date: 2008-04-01T20:50:48Z
• Authors: Sarah K. Meadows; Holly K. Dressman; Garrett G. Muramoto; Heather Himburg; Alice Salter; ZhengZheng Wei; Geoff Ginsburg; Nelson J. Chao; Joseph R. Nevins; John P. Chute
• Keywords: Gene signature; Acute exposure

BackgroundPrevious work has demonstrated the potential for peripheral blood (PB) gene expression profiling detection of disease or environmental exposures.Methods and FindingsWe have sought to determine impact several variables on PB profile an exposure, ionizing radiation, specificity signature radiation versus other genotoxic stresses. Neither genotype differences nor time sampling caused any lessening accuracy signatures predict but sex difference did influence prediction exposure at lowest level (50 cGy). A sepsis was also generated both were found be 100% specific distinguishing irradiated from septic animals. We identified human chemotherapy treatment which distinguished patients chemotherapy-treated individuals within a heterogeneous population with accuracies 90% 81%, respectively.ConclusionsWe conclude that profiles can in mice humans are accurate predicting medical conditions, each condition remain highly over time.